Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice
Key result
Leptin infusion completely reversed the increase in left ventricular wall thickness in obese mice, whereas caloric restriction did not, indicating leptin has weight-independent antihypertrophic effects.
Why the study?
Does leptin infusion reverse left ventricular hypertrophy independently of weight loss in leptin-deficient mice?
Population
Mice lacking leptin or functional receptor and controls, evaluated at 2, 4, and 6 months of age.
Comparison
Weight loss induced by either leptin infusion or… vs Placebo-treated controls.
Design
Preclinical
Follow-up
Evaluated at 2, 4, and 6 months of age; intervention in 6…
Authors
Discussion
Loading...
Member takes
Implication
May support leptin modulation for obesity-related LVH beyond weight loss; leaves open translation to human therapies.
Structured PICO
Does leptin infusion reverse left ventricular hypertrophy independently of weight loss in leptin-deficient mice?
P
Population
Mice lacking leptin (ob/ob, n=15) or functional receptor (db/db, n=10) and controls, evaluated at 2, 4, and 6 months of age.
I
Intervention
Weight loss induced by either leptin infusion or caloric restriction in 6- to 8-month-old ob/ob mice.
C
Comparator
Placebo-treated controls.
O
Outcome
Left ventricular (LV) wall thickness and LV mass measured with echocardiography.surrogate
Leptin has direct antihypertrophic effects on the heart independent of weight loss, suggesting that disruption of leptin signaling contributes to obesity-associated left ventricular hypertrophy.
Cite This Study
Barouch et al. (2003) studied Cardiac hypertrophy in obesity. Leptin infusion vs. Caloric restriction and placebo was evaluated on Left ventricular wall thickness and LV mass. Leptin infusion completely reversed the increase in left ventricular wall thickness in obese mice, whereas caloric restriction did not, indicating leptin has weight-independent antihypertrophic effects.