Peritoneal fibrosis (PF) is a significant factor in the failure of peritoneal dialysis (PD) techniques. Recent research has shown that histone lactylation levels increase with glycolysis and intracellular lactate levels, highlighting the impact of protein lactylation in regulating chronic organ injury. In this study, we investigated the role and mechanisms of histone lactylation in peritoneal fibrosis induced by high-glucose (HG) peritoneal dialysate in mice.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: