Kidney involvement in vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) is characterized by the presence of pauci-immune glomerulonephritis with crescent formation. However, this manifestation can also be found in severe cases of lupus nephritis (NL). Although 20% of patients with systemic lupus erythematosus (SLE) test positive for ANCA, cases have been described where patients meet classification criteria for both entities, known as overlap syndrome, which is extremely rare.
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Kortright et al. (2024) studied this question.
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