Steroid-resistant nephrotic syndrome (SRNS) is characterized by nephrotic-range proteinuria, hypoalbuminemia and edema that does not respond to steroid treatment. Its etiologies are diverse, including primary and secondary glomerulopathies, as well as genetic causes. It is noteworthy to highlight SRNS caused by variants related to coenzyme Q10 (CoQ10) biosynthesis, as this may be potentially treatable, in contrast to other SRNS causes that tend to progress to advanced chronic kidney disease (CKD) without therapeutic options.
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Garay et al. (2024) studied this question.
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