Podocyte injury, which involves the podocyte epithelialmesenchymal transition (EMT) process, is a crucial factor contributing to theprogression of diabetic nephropathy (DN) and proteinuria. Our study aimed toexamine the protective properties of Angiopoietin-like protein 3 (Angptl3)knockout on podocyte damage and macrophage polarization in DN mice andpodocytes treated with HG. Furthermore, we also sought to investigate theunderlying molecular mechanism responsible for these effects.
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Ma et al. (2024) studied this question.
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