June 1, 2008Acta Biochimica et Biophysica Sinica

Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin V3

View Full Paper

Ask AI

Bookmark

Why the study?

Does Angptl3 increase the permeability of human glomerular endothelial cells?

Population

Cultured human glomerular endothelial cells (GEnCs) in vitro

Comparison

Angiopoietin-like protein 3 (Angptl3) vs Untreated cells or cells treated with LY294002…

Design

Preclinical

Authors

YLYunling LiShenyang Pharmaceutical University LSLi SunTang Du Hospital HXHong XuAnhui Medical University

Discussion

Member takes

Implication

Angptl3 may promote glomerular barrier dysfunction in models; leaves open its role in human proteinuria and requires clinical validation.

Structured PICO

Does Angptl3 increase the permeability of human glomerular endothelial cells?

Population

Cultured human glomerular endothelial cells (GEnCs) in vitro

Intervention

Angiopoietin-like protein 3 (Angptl3)

Comparator

Untreated cells or cells treated with LY294002 (phosphatidylinositol-3 kinase inhibitor) or LM609 (integrin alphaVbeta3 antibody)

Outcome

Permeability of glomerular endothelial cells and level of protein kinase B phosphorylationsurrogate

Angptl3 increases glomerular endothelial cell permeability via a PI3K/PKB and integrin alphaVbeta3 pathway, suggesting a paracrine mechanism for proteinuria development.

Cite This Study

Li et al. (2008) studied this question.

synapsesocial.com/papers/6a8655e9e3ff5bf5642eced2 https://doi.org/10.1111/j.1745-7270.2008.00421.x

View Full Paper

Ask AI

Bookmark

Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin V3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin V3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider