Key result
Elevated serum ANGPTL3 levels are linked to hyperlipidemia, showing a ~2-fold increase over healthy controls.
Case-Control (n=91)
No
Absolute Event Rate: 87.86% vs 44.1%
p-value: p=0.015
May identify hyperlipidemia patients at proteinuria risk; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: Angiopoietin-like protein 3(ANGPTL3) is well acknowledged as a key regulator of lipid metabolism. Now, there have not been enough data to explain the mechanism of hyperlipidemia related proteinuria. In this study, we hoped to investigate the changes of Angiopoietin-like protein 3(ANGPTL3) levels in hyperlipidemia patients with different proteinuria levels. METHODS: Seventy-one patients with hyperlipidemia were selected, who were hospitalized in Gansu Provincial People's Hospital from September 2016 to September 2017, and 20 healthy people in the physical examination center were selected. We combed through medical history and conducted clinical biochemical indicators of blood urea nitrogen (BUN), serum creatinine (SCr), 24 h urine protein quantitation (24hUPro), cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low detection of density lipoproteins (LDL-C). The concentration of serum ANGPTL3 was measured by ELISA. RESULTS: 1. Serum ANGPTL3 in patients with hyperlipidemia related proteinuria was higher than that in the control group, and the difference was statistically significant (p < 0.05); 2. 24hUPro and BMI (r = 0.321, P = 0.002), TC (r = 0.465, P = 0.000), TG (r = 0.281, P = 0.007), LDL (r = 0.478, P = 0.000) in patients with hyperlipidemia related proteinuria are positively correlated, suggesting that dyslipidemia is related to the occurrence of proteinuria; 3. BMI, TC, TG and LDL in patients with hyperlipidemia related proteinuria were positively correlated with serum ANGPTL3. 4. The 24hUPro of patients with hyperlipidemia related proteinuria was positively correlated with serum ANGPTL3 levels, and BUN and SCr were not associated with serum ANGPTL3 level. 5. There was no significant difference in TC, TG, BMI, 24hUPro and serum ANGPTL3 between the statin-treated and the untreated groups in patients with hyperlipidemia related proteinuria. CONCLUSIONS: Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria.
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Gao et al. (2019) conducted a case-control in Hyperlipidemia related proteinuria (n=91). Hyperlipidemia vs. Healthy controls was evaluated on Serum ANGPTL3 concentration (ng/ml) (p=0.015). Serum ANGPTL3 levels were significantly elevated in patients with hyperlipidemia compared to healthy controls (87.86 vs 44.10 ng/ml) and positively correlated with 24-hour urine protein levels.
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