WCN24-1104 Finding of CD4+ T cells infiltrating the kidney of gddY mouse, IgA nephropathy animal model

In IgA nephropathy (IgAN), the mechanism by which IgA antibodies (Abs) are selectively deposited in the glomerular mesangial region has not been fully elucidated. We have recently uncovered its mechanism by identifying IgA type auto-Ab against mesangial antigens, βIIspectrin, in gddY mice, a spontaneous IgAN animal model and IgAN patients (Y. Nihei, H. Iwasaki and Y. Suzuki et al, Sci. Adv 2023). We also found that a significant number of IgA+ plasmablasts (PBs) accumulated in the kidneys of gddY mice and these PBs produced IgA autoAbs that bind to βII-spectrin and the surface of mesangial cells.