Hemodialysis is the renal replacement therapy (RRT) most used in the world. Online hemodiafiltration (OL-HDF) and high-flux hemodialysis (HF-HD) techniques demonstrated to be superior in the removal of medium molecular weight (MW) molecules with respect to conventional hemodialysis (CHD). These molecules are linked to an increased risk of cardiovascular events and death. Beta 2 microglobulin (B2M) is a medium PM molecule, in addition to being toxic, it is an example of the concentration of multiple molecules of the same group.
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Silvariño et al. (2024) studied this question.
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