The distribution of glomeruli in the kidney can be either in the superficial cortex, associated with short-looped nephrons (SLN), or in the deep cortex, associated with long-looped nephrons (LLN). Previous research has shown that LLN tend to exhibit greater glomerular hypertrophy and increased susceptibility to progressive changes. One common pathological feature in diabetic nephropathy (DN) is the alteration of mesangial morphology. This study uses artificial intelligence (AI)-based methods to compare mesangial morphomics between SLN and LLN in rat DN samples.
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Yang et al. (2024) studied this question.
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