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May 30, 2026Glomerular DiseasesOpen Access

Glomerular Structure and Function in Type 2 Diabetes Stratified by Glomerular Basement Membrane Thickening

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Authors

AMAmy K. MottlEEElif I. EkinciJBJohn M. Basgen

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Overview

Randomized trial examined glomerular function in type 2 diabetes, indicating distinct structural features based on GBM thickness.

Key Points

  • This research explores the structural-functional relationships of the glomeruli in type 2 diabetes, focusing on the effects of GBM thickening.
  • Conducted kidney biopsies in 30 individuals with type 2 diabetes and specific baseline characteristics.
  • Performed stereologic analyses and light microscopy for glomerular lesions in a subset (N=19) with available tissue.
  • Calculated eGFR slope and collected creatinine values to assess renal function.
  • GBM thickening occurred in 21 of 30 participants, associated with higher HbA1c (7.9% vs 6.6%).
  • In the GBM thickened group, significant correlations with eGFR slope were observed (R=-0.4 for mesangium, R=-0.5 for mesangial matrix, R=-0.5 for podocyte foot process width, all p<0.05).
  • The subgroup without GBM thickening showed varying degrees of vascular lesions and hypertensive nephrosclerosis.

Cite This Study

Mottl et al. (2026) studied this question.

synapsesocial.com/papers/6a1a80550307b78509432486https://doi.org/10.1159/000552638
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