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October 1, 2000Nephrology Dialysis TransplantationOpen Access

Antihypertensive treatment arrested the increase in interstitial fractional volume seen in untreated patients (untreated group increased P=0.0009, beta-blocker decreased P=0.03, ACEi no change).

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Why the study?

Does antihypertensive treatment prevent structural renal changes in microalbuminuric type 1 diabetic patients?

Population

21 microalbuminuric type 1 diabetic patients with diabetes duration of 6-16 years

Comparison

Antihypertensive treatment with either… vs Reference group without antihypertensive…

Design

Cohort

Authors

RØRuth ØsterbyHBHans‐Jacob BangstadSRSusanne Rudberg

Discussion

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Overview

Antihypertensives may arrest renal interstitial expansion in microalbuminuric type 1 diabetes; hypothesis-generating and requires randomized confirmation.

Structured PICO

Does antihypertensive treatment prevent structural renal changes in microalbuminuric type 1 diabetic patients?

P
Population
21 microalbuminuric type 1 diabetic patients with diabetes duration of 6-16 years
I
Intervention
Antihypertensive treatment with either angiotensin-converting enzyme-inhibitor (n=6) or beta-blocker (n=6)
C
Comparator
Reference group without antihypertensive treatment from a previously completed study (n=9)
O
Outcome
Changes in glomerular volume, vascular pole area, and interstitial space expressed as fraction of tubular cortexsurrogate

Antihypertensive treatment with ACE inhibitors or beta-blockers arrests the progressive increase in renal interstitial volume fraction in early microalbuminuric type 1 diabetic patients.

Cite This Study

Østerby et al. (2000) studied this question.

synapsesocial.com/papers/6a72dcf744a81065fbf3cfc5https://doi.org/10.1093/ndt/15.10.1609
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