WCN24-797 Roles of Irisin, a myokine on uremic sarcopenia

The prevalence of sarcopenia is high in patients with CKD. Furthermore, sarcopenia has been reported to be closely associated with decreased physical activity and mortality. Recently, attention has focused on the secretion of bioactive substances called myokines from skeletal muscle immediately after exercise, which is associated with improved metabolism and increased muscle mass. Irisin, one of the myokines, has been shown to play an important role in maintaining endothelial function. Furthermore, Irisin is known to be decreased in the pathogenesis of CKD, and its level is associated with the severity of atherosclerosis in CKD.