Murine nephrotoxic nephritis is a widely used model of immune-complex-mediated glomerulonephritis. In this model, mice are immunized with normal sheep IgG, followed by administration of a sheep antiserum (nephrotoxic serum or NTS) raised against mouse glomerular components. This leads to glomerular injury, concomitant albuminuria and an increase in serum creatinine level. The Src-family kinases Hck, Fgr, and Lyn are critical for various disease models. However, their role in kidney diseases is poorly understood.
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Lesinszki et al. (2024) studied this question.
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