Gross hematuria (GH) is observed shortly after an upper respiratory tract infection in 30–40% of the patients with immunoglobulin A nephropathy (IgAN), however, its mechanism and the renal outcome are unclear. Recently, several reports showed the cases with GH after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in patients with IgAN. Here, we sought to clarify the mechanism of GH in IgAN by detailing the clinical characteristics and measuring serum and urinary galactose-deficient IgA1 (Gd-IgA1), which are known to be associated with development of IgAN, in patients with GH after coronavirus disease 2019 (COVID-19) vaccination.
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Aoki et al. (2024) studied this question.
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