Atypical hemolytic uremic syndrome (aHUS) is an entity characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multisystemic organ dysfunction. Histologically, it is characterized by endothelial damage, widening and edema of the subendothelial space due to cell lysis material, and the subsequent presence of thrombi obstructing capillary lumen. It presents with a prevalence of 0.5 -1% per million population and approximately 50% of subjects develop end-stage kidney disease.
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Ursino et al. (2024) studied this question.
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