Lysozyme-induced nephropathy is a rare kidney manifestation mostly associated with hematologic diseases, especially Chronic Myelomonocytic Leukemia (CMML). This nephropathy is rare, underrecognized and underestimated in this population. Lysozyme is a 15 kDa cationic protein, produced mainly by monocytes and macrophages. The disease pathogenesis is not well understood; however, it is probably related to lysozyme's direct tubular injury after endocytic reabsorption by proximal tubules, leading to ischemic tubular damage.
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Ferreira et al. (2024) studied this question.
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