Case report shows improvement in lysozyme-induced nephropathy in chronic myelomonocytic leukemia patients, suggesting effective treatment options.
【Introduction】 Lysozyme is a low molecular weight protein of 15 kilodaltons produced by monocytes and macrophages. It is freely filtered by the glomerulus and reabsorbed in the proximal tubule. In monocytic leukemias such as chronic myelomonocytic leukemia (CMML), excessive lysozyme production may occur. This excess lysozyme deposits in the proximal tubules, causing a rare acute kidney injury termed lysozyme-induced nephropathy (LyN).
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Fukaya et al. (2026) studied this question.
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