Systematic review highlights emerging pediatric kidney damage in endemic communities, suggesting early childhood exposures contribute to chronic kidney disease of unknown etiology.
Chronic kidney disease of unknown etiology (CKDu) is a tubulointerstitial disease that disproportionately affects young, primarily male, agricultural workers in Mesoamerica and South Asia who lack traditional risk factors for kidney disease. Extensive research in adult populations suggests the etiology is multifactorial and indicates that early childhood exposures could have an integral role. Evaluating subclinical kidney disease in children is important both for identification of prevention strategies and to understand relevant exposures.
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Strasma et al. (2024) studied this question.
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