IgA nephropathy (IgAN) is the most common primary glomerulonephritis and a significant contributor to ESKD worldwide. Hematuria is an indicator of IgAN activity representing active glomerulonephritis and resolution is associated with improved renal outcomes. IgAN is characterized by elevated serum levels of galactose-deficient IgA1 (Gd-IgA1). High Gd-IgA1 levels are associated with greater risk of renal function deterioration, ESKD, and death, and Gd-IgA1 reduction has been correlated with hematuria remission.
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Barratt et al. (2024) studied this question.
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