Hypertension is a major independent risk factor for chronic kidney diseases. However, the exact pathologic mechanisms of hypertensive renal fibrosis are still unknown. Our preliminary studies demonstrated that dysregulated activation of the key developmental signaling pathway Wnt/βcatenin controls renin angiotensin system (RAS) expression, which promote the pathogenesis of hypertension and renal fibrosis. Interestingly, we recently identified the positive feedback loop between prorenin receptor (PRR) and Wnt/β-catenin signaling promotes renal fibrosis.
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Lin et al. (2024) studied this question.
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