Key result
Prorenin receptor upregulation contributes to hypertension, glomerular injury, and kidney disease progression.
Why the study?
To highlight the function of the (pro)renin receptor in renal inflammation under pathophysiological conditions.
The (pro)renin receptor plays a significant pathological role in renal inflammation and the development of hypertension and kidney disease.
May identify a novel target in hypertension and CKD; leaves open whether inhibition improves outcomes in trials.
(Pro)renin receptor (PRR) is the recently discovered component of the renin-angiotensin-aldosterone system (RAS). Many organs contain their own RAS, wherein PRR can exert organ-specific localized effects. The Binding of prorenin/renin to PRR activates angiotensin-dependent and independent pathways which leads to the development of physiological and pathological effects. Continued progress in PRR research suggests that the upregulation of PRR contributes to the development of hypertension, glomerular injury, and progression of kidney disease and inflammation. In the current review, we highlight the function of the PRR in renal inflammation in pathophysiological conditions.
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Quadri et al. (2021) conducted a review in Renal inflammation and kidney disease. (Pro)renin receptor (PRR) was evaluated. Upregulation of the (pro)renin receptor contributes to the development of hypertension, glomerular injury, and progression of kidney disease and renal inflammation.
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