Why the study?
To summarize current advances in PRR biology, address unresolved mechanistic questions, and evaluate its therapeutic potential in cardiometabolic and renal diseases.
Design
Review
Key result
The prorenin receptor (PRR) plays an indispensable role in tissue homeostasis, and its dysregulated signaling is implicated in the progression of cardiovascular, renal, and metabolic diseases.
Authors
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PRR expands the classical RAAS paradigm; leaves open targeted therapeutic translation in cardiovascular disease.
The prorenin receptor (PRR) plays a multifaceted role in cardiovascular and metabolic diseases, highlighting its potential as a future biomarker and therapeutic target.
Marrero-Bras et al. (2026) conducted a review in Cardiovascular, renal, and metabolic diseases. Prorenin receptor (PRR) was evaluated. The prorenin receptor (PRR) plays an indispensable role in tissue homeostasis, and its dysregulated signaling is implicated in the progression of cardiovascular, renal, and metabolic diseases.