M-type phospholipase A2 receptor(PLA2R) is a major autoantigen of primary membranous nephropathy(PMN) and anti-PLA2R antibody levels are closely associated with disease severity and therapeutic effectiveness.With the investigation of the immunological epitopes of the PLA2R antigen,the knowledge of the immunological pathogenesis of PMN has been deepened.As the analysis of epitope reactivity may have a predictive value greater than that of PLA2R-antibody level,our study aimed to discover the relationship between domain specific antibody levels and clinical outcome of patients with PMN.
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Zhou et al. (2024) studied this question.
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