Chronic Kidney Disease (CKD) is characterized by progressive kidney damage evidenced by a reduction in the glomerular filtration rate. Cognitive dysfunction is common in patients with CKD and the exact physiopathology of cognitive impairment in CKD is not completely understood. Biomarkers related to vascular endothelial injury are elevated in CKD patients on hemodialysis. Serum levels of Klotho protein are significantly lower in patients with CKD than in healthy patients, also reducing cerebral Klotho levels.
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Queiroz et al. (2024) studied this question.
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