Wcn24-638 Luminal Immune Surveillance of Filtered Antigens: Implications for Adaptive Immune Responses in the Kidney

This is the authors' abstract. We don't add key points for this paper.

The adaptive immune system contributes to renal inflammation and diseases of both native and transplanted kidneys. Understanding the precise mechanisms of immune regulation in the kidney will lead to improved therapies for renal auto and alloimmune diseases. The kidney is an organ that specializes in molecular transport and contains a network of renal mononuclear phagocytes (rMPCs) that patrol the bloodstream for pathogens and other molecules. We hypothesized that the proximal tubule's transport function contributes to renal immune surveillance by reabsorbing and enhancing uptake of filtered antigens by major histocompatibility complex (MHCII)-expressing rMPCs.