Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) diagnosed via histopathology of renal biopsy. Investigating surrogate markers to predict renal involvement in LN is a safe non-invasive method to be studied. One of those markers is Interleukin 35 (IL-35) which has an immunosuppressive and anti-inflammatory role in many autoimmune diseases. However, its role in LN still needs to be elucidated. This study aimed to evaluate serum levels of IL-35 in SLE patients with and without LN as a biomarker of renal involvement.
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Ghanem et al. (2024) studied this question.
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