Primary hyperoxaluria (PH) is an autosomal recessive genetic defect of hepatic glyoxylate metabolism, with increased endogenous oxalate production. Oxalate is excreted almost exclusively by the kidneys. This overproduction causes the formation of calcium oxalate crystals, with the consequent formation of nephrolithiasis and nephrocalcinosis.
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Angulo et al. (2024) studied this question.
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