Wcn24-2154 Antioxidant and Mitochondrial Effects of Osthole in a Model of Contrast Induced-Acute Kidney Injury (Ci-Aki)

Administration of contrast media may cause contrast-induced nephropathy (CIN), which is a severe complication during angiographic studies; it is the third most common cause of iatrogenic acute kidney injury, accounting for approximately 12% of all cases and can lead to chronic kidney disease. CIN is a sudden elevation of serum creatinine of more than 25% or ≥0.5 mg/dl in the first 48 hours. The pathological mechanisms include tubular toxicity, intrarenal vasoconstriction, and increased oxidative stress.