Design of a Biohybrid Materials Circuit with Binary Decoder Functionality (Adv. Mater. 14/2024)

Information-Processing Materials Biohybrid materials that communicate with each other via diffusible inhibitory or activating signals are assembled in a circuit topology inspired by an electronical binary 2-input/4-output decoder. The biomolecular decoder is programmed to convert specific binary molecular inputs into the release of distinct protease outputs. Such information-processing biohybrid material circuits can be used for biomolecular computing and sensor signal processing. More details can be found in article number 2308092 by Wilfried Weber and co-workers.