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April 1, 2024Molecular Nutrition & Food Research

Modifying Effects of Genetic Variations on the Association Between Dietary Isothiocyanate Exposure and Non‐muscle Invasive Bladder Cancer Prognosis in the Be‐Well Study

Zinian Wang Marilyn L. Kwan Reina Haque Prashant Kumar Singh Maciej Ł. Goniewicz Rachel Pratt Valerie S. Lee Janise M. Roh Isaac J. Ergas Kimberly L. Cannavale Ronald K. Loo David S. Aaronson Charles P. Quesenberry Yuesheng Zhang Christine B. Ambrosone Lawrence H. Kushi Li Tang

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Abstract

Dietary isothiocyanate (ITC) exposure from cruciferous vegetable (CV) intake may improve non-muscle invasive bladder cancer (NMIBC) prognosis. This study aims to investigate whether genetic variations in key ITC-metabolizing/functioning genes modify the associations between dietary ITC exposure and NMIBC prognosis outcomes.

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Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e713e5b6db64358768d027 https://doi.org/10.1002/mnfr.202400087

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Outcomes of a Dietary Intervention to Reduce Bladder Cancer Recurrence and Progression in Survivors of Non–Muscle-Invasive Bladder Cancer2024 · 8 citations
2Cruciferous Vegetable Intervention to Reduce the Risk of Cancer Recurrence in Non–Muscle-Invasive Bladder Cancer Survivors: Development Using a Systematic ProcessReview · 2022 · 8 citations
3The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and updateHuman Clinical Trial · 2024 · 11 citations
4The Chemopreventive and Anticancer Potential of Glucosinolates and Their Hydrolysis Products from Cruciferous VegetablesNarrative Review · 2026 · 5 citations
5A Review on Varied Mechanistic Pathways of Four Major Isothiocyanates in Cancer Suppression and Their Synergistic Action in Cancer TherapyReview · 2026

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Abstract RF1-07: Cruciferous vegetable intake, dietary glucosinolate and risk of breast cancer in 2 large prospective studies2026
Bioavailability, Human Metabolism, and Dietary Interventions of Glucosinolates and Isothiocyanates: Critical Insights and Future Perspectives2025
Therapeutic potential of isothiocyanates by targeting the NRF2 pathway2026

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