Effect of Implementing Bundle of Care on Breast Cancer Patients Paclitaxel Induced Peripheral Neuropathy and Quality of Life

Background: Breast cancer is the most often diagnosed disease and the main cause of death between females globally. Different chemotherapeutic are used, such as doxorubicin or epirubicin in combination with cyclophosphamide, and paclitaxel (Taxol) or docetaxel in combination with carboplatin Aims: the study aimed to evaluate effect of implementing bundle of care on breast cancer patients paclitaxel induced peripheral neuropathy and quality of life. Methods: Research Design: A quasi-experimental research design was used to conduct the study. Subjects: A purposive sample of 60 adult subjects newly diagnosed with breast cancer and treated with paclitaxel. Setting: This study was conduct at oncology treatment center and nuclear medicine department at Qena university hospital. Data collection Tools: Four tools were used for data collection: Tool I: Breast cancer patient's structured interview questionnaire. Tool II: The Chemotherapy Induced Peripheral Neuropathy Assessment (CIPNA). Tool III: Functional Breast (FACT-Tool IV. Neuropathy Grading Assessment Scale. Results: The mean Assessment of Cancer Therapy scores of PIPN -QOL for the study group increased one and two months after bundle of care implementation compared to upon admission in the study with highly statistically significant differences between them at p < 0.001. Statistically significant differences regarding sensory and motor neuropathy grading (G1, G2, G3, and G4) was found after one and after two months of implementing bundle of care instructions between both group p≤ 0.05. Conclusion: Implementing bundle of care has a positive effect on PIPN-QOL. The study group demonstrates a statistically significant Vol. 33. No.2 May, 2024 287 Tanta Scientific Nursing Journal (Print ISSN 2314 – 5595 ) ( Online ISSN 2735 – 5519) improvement regarding sensory/motor neuropathy grading and quality of life. Recommendations: The bundle of care instructions should serve as the basis for routine nursing care for patients receiving paclitaxel to improve their peripheral neuropathy and quality of life.