Case report shows clinical improvement with steroid treatment in a 52-year-old male with anti-LGI1 encephalitis, highlighting the value of early therapy and long-term monitoring for recurrence.
Anti-leucine-rich glioma-inactivated 1 encephalitis is an autoimmune encephalitis which is also considered as a subtype of limbic encephalitis characterised by acute or subacute cognitive impairment, faciobrachial dystonic seizures, psychiatric disturbances and hyponatremia.Here we present a case of a 52 year old male with anti-LGI1 limbic encephalitis along with acute changes in mental status, hyponatremia and faciobrachial dystonic seizure who showed improvement with steroid treatment.Our case demonstrated the need to have high suspicion for LG1 antibody associated encephalitis in patients who present with rapidly progressive dementia along with FBDS which is reversible and treatable.Early treatment with immunomodulatory drugs can reverse the disease.Most importantly we should follow up the patient for a long time to monitor the possibility of recurrence.
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Byju et al. (2024) studied this question.
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