What question did this study set out to answer?

To characterize the clinical features and brain MRI abnormalities in patients with faciobrachial dystonic seizures associated with LGI1 autoantibodies.

October 2, 2015Neurology Neuroimmunology & NeuroinflammationOpen Access

Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures

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Authors

EFEoin P. FlanaganMayo Clinic AKAmy L. KotsenasMayo Clinic JBJeffrey W. BrittonMayo Clinic

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Implication

Retrospective case series finds basal ganglia T1 hyperintensity in LGI1-antibody faciobrachial dystonic seizures, suggesting specific basal ganglia localization.

Key Points

To characterize the clinical features and brain MRI abnormalities in patients with faciobrachial dystonic seizures associated with LGI1 autoantibodies.
Retrospectively analyzed 48 patients with LGI1-autoantibody encephalopathy identified from a clinical and serologic database (2002–2015).
Evaluated clinical, electroencephalographic, and neuroimaging features of 26 patients with confirmed faciobrachial dystonic seizures.
Blinded comparison of brain MRIs between patients with faciobrachial dystonic seizures (n=26) and without (n=22) performed by two neuroradiologists.
Basal ganglia MRI abnormalities were present in 11 of 26 patients with FBDS (42%) and 0 of 22 without FBDS (p < 0.001), whereas mesial temporal abnormalities were less common with FBDS (42% vs 91%, p < 0.001).
Basal ganglia findings included T1 hyperintensity alone (2), T2 hyperintensity alone (1), or both (8), with T1 changes persisting significantly longer than T2 changes (median 11 weeks vs 1 week, p = 0.02).
Clinical improvement occurred in 18 of 18 patients treated with immunotherapy compared to 10 of 24 treated with standard antiepileptic medications.

Cite This Study

Flanagan et al. (2015) studied this question.

synapsesocial.com/papers/6a87df329842aaac2ffb1641 https://doi.org/10.1212/nxi.0000000000000161

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Implication

Retrospective case series finds basal ganglia T1 hyperintensity in LGI1-antibody faciobrachial dystonic seizures, suggesting specific basal ganglia localization.

Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures

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Cite This Study

Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures

Discussion

Member takes

Implication

Key Points

Cite This Study

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