Acute Lymphoblastic Leukemia with Central Nervous System Relapse: Case series of unusual presentation

Central nervous system (CNS) relapse in acute lymphoblastic leukemia (ALL) was and still is a major site for relapse that adversely affects the cure rate.This is a retrospective case series, the characteristics of three diagnosed with early and late, isolated CNS and combined B-ALL relapse after initial frontline therapy were reported.The present study throws the shades on three of the rare and unusual presentation of relapsed CNS lymphoblastic leukemia among children, with challenges in early diagnosis and affirmation of the importance of appropriate CNS directed therapy.