Preliminary study on vascular-targeted polyphenol nanoparticles in photodynamic therapy of port-wine stains

A combination of polyphenol with near infrared photodynamic therapy (PDT) and vascular-targeting nanoparticles holds significant promise as a potential treatment for port-wine stains (PWS). The anti-angiogenic properties of the polyphenol, along with the targeted approach of the nanoparticles and the ability of PDT to selectively damage tissue, make this treatment approach particularly compelling. Using EOMA cells for invitro experiment to examine the anti-angiogenesis effects of PDT using ELC, which is self-assembly Epigallocatechin-3-gallate (EGCG) nanoparticles loading with Ce6 photosensitizer. In comparison to free Ce6, ELC resulted in increased intracellular uptake of Ce6, leading to improved cytotoxicity when used with laser while maintaining good biocompatibility. Furthermore, ELC enhanced the generation of reactive oxygen species (ROS) within cells. However, ELC did not demonstrate any advantages in inducing apoptosis. PDT using ELC is a promising method for PWS.