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April 1, 2024Fayoum University Medical Journal/Fayoum University Medical Journal Open Access

Association of Udp-Glucoronyl Transferase 1-A7 Polymorphism at Codon 208 With Hepatocellular Carcinoma and Liver Cirrhosis

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Authors

HEHaytham Abdelrahman ElnaggarNMNehad MosaadCairo UniversityIRIman Ismael RamzyCairo University

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Overview

Observational study reveals increased UGT1A7 codon 208 variants in hepatocellular carcinoma patients, indicating that this polymorphism represents a major risk factor for liver malignancy.

Key Points

  • Hepatocellular carcinoma is significantly associated with UGT1A7 codon 208 gene polymorphisms, showing elevated frequencies of variant alleles.
  • Melting curve analysis of 70 patients revealed higher UGT1A7 codon 208 heterozygous and homozygous genotypes in tumor cases than in controls.
  • Highlights that UGT1A7 codon 208 alterations act as critical risk factors for liver cirrhosis and subsequent hepatocellular carcinoma onset.

Cite This Study

Elnaggar et al. (2024) studied this question.

synapsesocial.com/papers/68e7170bb6db643587690703https://doi.org/10.21608/fumj.2024.262880.1306
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