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Black cumin (Nigella sativa) seed oil contains thymoquinone and saponins, can be used to treat inflammation. This study aims to obtain a nanoparticle emulsion gel preparation of black cumin seed oil that has anti-inflammatory activity of wound healing in rabbit experimental animals. The preparation was made with a gel base (F1), a gel formula with black cumin extract (F2), and a black cumin extract gel formula with nanoparticle emulsion (F3). Evaluation of the preparation was carried out for eight weeks, including pH, organoleptic, homogeneity, dispersibility, and stability tests. A particle size analyzer (PSA) test was carried out to assess the size of nanoparticles. The activity test was carried out by observing the wound. The results of the pH test of the three formulations in the normal skin pH interval are 4.5–6.5. The evaluation results of the three formulations showed they were stable. The results of the homogeneity test of the three formulations showed that the preparations were homogeneous during storage. The gel spreadability test is good, with a minimum and maximum range of 5 to 7 cm after being given a load of 150 g and a very comfortable semisolid consistency.
Syapitri et al. (Sun,) studied this question.