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Malaria is a life challenging disease that occurred as a resut of infection by single celled parasitic microorganisms.Mainly, it is transmitted by female anopheles mosquito of plasmodium family.Chloroquine is the cheapest antimalarial drug candidate available worldwide.Since 1957, Chloroquine and some other quinine derivatives resistance has been observed by P. falciparum in the southeast Asia region like Cambodia, Thailand, Myanmar, and Vietnam country.The same resistance has been extended since 1970, and it has been emerged in several parts of India.Furthermore, chloroquine is having a far more adverse effects like nausea, vomiting, blurred vision, headache, abdominal cramp, deprivation of appetite, diarrhoea, hearing loss, baldness, change in skin color, decresed body weight, seizures.Further, this drug cannot be prescribed to the pregnant women.Accordingly, it is a necessary thing to invent some newer and potential antimalarial drug candidates so that the drug resistance along with side effects can be well overcome.In this present review, we have incorporated the essence of research articles by the research scientists from disparate countries and assassinated an endeavor to report P. falciparum chloroquine resistance developed as a result of mutations in pfcrt and pfmdr1 gene.Docking study revealed that NADP dependent P. falciparum glutamate dehydrogenase is a putative target enzyme for the design and development of contemporary antimalarial medicaments.
Sn et al. (Sun,) studied this question.