Identifying Atypical Familial SLE in the American Indian/Alaska Native Population

Systemic lupus erythematosus (SLE) is a major chronic systemic inflammatory autoimmune condition that affects all demographics of the population; however, it is typically thought to be a disease primarily of females since about 9 in 10 diagnosed cases are in female patients. While there are studies describing the prevalence of disease in the American Indian/Alaska Native (AI/AN) population, few individual cases are highlighted. We present a pair of cases among two AI/AN full-blood brothers, who are members of the Cherokee Nation (CN), Oklahoma.