Objective : Previous observational research has indicated an association between plasma selectin family members and endometriosis, and our objective was to investigate the causal association between selectins and endometriosis. Methods : Using pooled statistics from genome-wide association studies of predominantly European ancestry and utilizing Mendelian randomization (MR), we analyzed the causal effect of the selectins E/P/L on endometriosis and the causal association of selectins with endometriosis at different sites. Results : This study revealed a causal relationship between E-selectin and endometriosis (ratio of 0.92, 95% CI (0.86, 0.98) p = 0.01). And the causal relationship between selectins and endometriosis at different sites. Conclusion : Our genetic predictions suggest that higher levels of selectins may provide protection against endogamy and may serve as therapeutic targets in the future.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: