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March 28, 2024Open Access

FIGURE 3 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases

Koichi Ito Ibuki Harada Criseyda Martinez Katsutoshi Sato Eunjee Lee Elisa Port Jessica H. Byerly Anupma Nayak Ekta Tripathi Jun Zhu Hanna Y. Irie

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Abstract

MARCH2 is a novel PTK6-regulated SNAIL E3 ligase. A, Schema of siRNA screening strategy used to identify PTK6-regulated SNAIL E3 ligases. B, MARCH2 siRNA (SMART Pool) identified as top candidate siRNA that restores SNAIL expression in P21d-treated MDA-MB-231/SNAIL- Luciferase cells by Western analysis. C, MARCH2 siRNA (SMART POOL or individual) prevents P21d-induced SNAIL downregulation in MDA-MB-231 cells.

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Cite This Study

Ito et al. (2024) studied this question.

synapsesocial.com/papers/68e71feab6db643587699c31 https://doi.org/10.1158/2767-9764.25499295.v1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1FIGURE 5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases2024
2Figure S8 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases2024
3Figure S7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases2024
4Figure S5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases2024
5Figure S6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases2024