Consequences of giving birth to women carriers of antibodies to thyroid peroxidase

Aim of the research - to analyze obstetric and perinatal complications of pregnancy and childbirth, the condition of newborn babies, pregnant women carriers of antibodies to thyroid peroxidase (TPOAb) in order to improve the effectiveness of their diagnosis and prevention. Materials and methods. A retrospective study was conducted of 140 histories of pregnancy and childbirth of women carriers of TPOAb, as well as the histories of their newborns - the main group (MG).The criteria for inclusion in the main group was the presence of an TPOAb titer higher than 100 IU/ml. The comparison group (CG) consisted of 40 birth histories of women without an elevated level of TPOAb, somatic pathology and with a physiological course of the gestational period, as well as 40 histories of their newborns. Statistical processing of research results was carried out using standard Microsoft Excel 5.0 and Statistica 6.0 programs. Results. It was established that female patients carrying TPOAb have a higher percentage of the following gestational complications: threats of termination of pregnancy (pregnancy in MG was terminated in 6 cases: frozen pregnancy in 2 (1.4%) cases, spontaneous abortion in the I trimester - 3 (2.1%) cases, spontaneous abortion in the II trimester - 1 (0.7%) case; threats of premature birth - 13 (9.3%) cases; fetal growth restriction syndrome - 8 (5.7%) cases; preeclampsia 22 (15.7%) cases against 2 (5.0%), p<0.001. Premature birth was observed only in MG patients and accounted for 24 (17.9%) cases. The rate of pathological labor was significantly different in the research groups. A high specific weight of pathological births childbirth was observed in women carriers of TPOAb - 47 (35.1%) cases in CG versus 4 (10.0%) cases in CG, p<0.05. Cesarean section was performed in 38 (27.1%) patients MG and 3 (7.5%) pregnant women CG. Conclusions. In the course of the retrospective study, it was revealed that women carriers of TPOAb have a higher percentage of the development of such gestational and perinatal complications as the threat of abortion and miscarriage, fetal distress, preeclampsia of various degrees of severity, pathological childbirth and asphyxia of newborns compared to patients with normal level of TPOAb. The research was conducted according to principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution indicated in the work.The informed consent of women was obtained for conducting the study. No conflict of interests was declared by the authors.