Frequency of hypotension after intravenous streptokinase in patients presenting with ST elevation myocardial infarction

INTRODUCTION: One of the primary causes of death and disability worldwide is Acute Myocardial Infarction. Streptokinase is still widely used in many countries for its treatment, despite percutaneous advancements in the field. This study was conducted to appraise the incidence with which hypotension occurred by streptokinase in patients suffering from acute ST-elevation Myocardial Infarction (STEMI) due to the significance of this disease and the potential side effects of streptokinase to the patient. The purpose of this study was to ascertain the frequency of hypotension in patients presenting with ST Elevation Myocardial Infarction, who are being administered streptokinase. METHODOLOGY: The study was conducted at the Emergency Department of Punjab Institute of Cardiology, Lahore from August 25, 2020 to February 25, 2021. A total 280 patients with STEMI were enrolled in the study. Electrocardiographic diagnosis of ST Elevation Myocardial Infarction was performed by a consultant cardiologist. Bedside echocardiography was also performed by a consultant cardiologist. Manual blood pressure recording of the patients was carried out every five minutes during administration of Streptokinase Injection and every hour and three hours after completion. Data was input and analysed using SPSS v25.0. To account for these impact modifiers, we stratified the data according to age, gender, diabetes status, family history, smoking status, and hypercholesterolemia. The chi-square analysis will be performed when the stratification process is complete. A p-value of 0.05 or below was taken to be of statistical significance. RESULTS: A total of 280 patients with STEMI were selected for this study. There were 165(58.9%) males and 115(41.1%) females. Mean age was 38.46±9.81 year. Among 280 patients with STEMI, 39(13.9%) patients had hypotension. CONCLUSION: Streptokinase, given intravenously, had lower incidence of cardiovascular complications like hypotension. A future with less illness burden may be possible if we take a more targeted approach to lowering the risks that contribute to it via health education and promotion.