Key result
Intravenous streptokinase therapy achieved complete ST segment resolution in 41.7% of patients with acute STEMI, with lack of resolution associated with increased adverse events and mortality.
Why the study?
Streptokinase remains widely used due to availability and low cost, but data were needed to assess its efficacy via ST-elevation resolution and predict short-term in-hospital outcomes in acute STEMI.
Does IV streptokinase improve ST-elevation resolution in acute STEMI patients?
Observational (n=60)
No
Does IV streptokinase improve ST-elevation resolution in acute STEMI patients?
IV streptokinase achieves complete ST resolution in approximately 42% of acute STEMI patients, and failure to achieve resolution at 90 minutes predicts worse in-hospital outcomes.
Failure to achieve ST resolution after streptokinase identifies high-risk STEMI; supports prognostic use but leaves open comparative efficacy trials.
Background: Acute Myocardial Infarction is one of the leading causes of mortality and morbidity. Now there are a number of drugs for Thrombolysis but still Streptokinase is used in many of the centers because of the ease of availability and less cost. ST segment elevation resolution following thrombolysis is simple, non-invasive, accessible tool for the assessment of coronary reperfusion. Objective of the present study was to assess the efficacy of thrombolysis in Acute STEMI patients, with respect to resolution of ST-elevation on treatment with streptokinase and also to predict short term outcome during hospital stay in terms of adverse events and mortality.Methods: 60 Acute STEMI patients who had received thrombolytic therapy with streptokinase were studied in three groups namely Category A, Category B and Category C based on ST segment resolution after administration of thrombolytic therapy.Results: Of 60 patients, 9 patients (15%) had <30% ST resolution (no STR), 26 patients (43.3%) had 30-70% ST resolution (partial STR), 25 patients (41.7%) had >70% ST resolution (complete STR).Conclusions: In the present study we conclude that the efficacy of IV streptokinase for thrombolysis in acute STEMI is 41.7%. Patients with no resolution of ST segment 90 minutes following thrombolysis associated with more frequent adverse events and increased mortality compare to partial and complete resolution group.
No takes yet. Share an insight, caveat, or question.
Karthik et al. (2019) conducted an observational in Acute ST elevation myocardial infarction (n=60). IV streptokinase was evaluated on Complete ST segment resolution (>70%) at 90 minutes. Intravenous streptokinase therapy achieved complete ST segment resolution in 41.7% of patients with acute STEMI, with lack of resolution associated with increased adverse events and mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: