What does this research mean for the field?

Administering alteplase as rescue thrombolytic therapy in acute myocardial infarction patients who fail to reperfuse after initial streptokinase treatment significantly reduces infarct size and improves left ventricular ejection fraction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1995HeartOpen Access

Rescue thrombolysis: alteplase as adjuvant treatment after streptokinase in acute myocardial infarction.

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Why the study?

Does rescue thrombolysis with alteplase improve left ventricular ejection fraction and reduce infarct size in acute myocardial infarction patients who fail to reperfuse after streptokinase?

Population

37 patients with acute myocardial infarction who showed electrocardiographic evidence of failed reperfusion…

Comparison

Alteplase 100 mg over three hours vs Placebo

Design

RCT, randomly allocated

Follow-up

4-6 weeks after discharge

Authors

JMJ. P. D. MounseyUniversity of North Carolina at Chapel Hill JSJane SkinnerUniversity of East Anglia THT HawkinsFreeman Hospital

Discussion

Member takes

Implication

Supports rescue alteplase after streptokinase failure; extends thrombolysis evidence to non-reperfused AMI.

Structured PICO

Does rescue thrombolysis with alteplase improve left ventricular ejection fraction and reduce infarct size in acute myocardial infarction patients who fail to reperfuse after streptokinase?

Population

37 patients with acute myocardial infarction who showed electrocardiographic evidence of failed reperfusion (<25% reduction of ST elevation) 30 minutes after 1.5 MU streptokinase over 60 minutes, plus 43 control patients with electrocardiographic evidence of reperfusion.

Intervention

Alteplase 100 mg over three hours

Comparator

Placebo

Outcome

Electrocardiographic infarct size assessed from the Selvester Q wave score of a predischarge electrocardiogram and left ventricular ejection fraction assessed by nuclear gated scan 4-6 weeks after dischargesurrogate

Rescue thrombolysis with alteplase reduces infarct size and improves left ventricular ejection fraction in acute myocardial infarction patients who fail initial reperfusion with streptokinase.

Cite This Study

Mounsey et al. (1995) studied this question.

synapsesocial.com/papers/6a1c07cc5b8f4ede65a96b87 https://doi.org/10.1136/hrt.74.4.348

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Rescue thrombolysis: alteplase as adjuvant treatment after streptokinase in acute myocardial infarction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rescue thrombolysis: alteplase as adjuvant treatment after streptokinase in acute myocardial infarction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider