What question did this study set out to answer?

To assess the short- and long-term efficacy, safety, and coronary artery patency following high-dose intravenous streptokinase in patients with acute myocardial infarction.

March 1, 1986HeartOpen Access

High dose intravenous streptokinase in acute myocardial infarction--short and long term prognosis.

View Full Paper

Ask AI

Bookmark

Why the study?

Does high dose intravenous streptokinase induce reperfusion in patients with acute myocardial infarction?

Key Points

To assess the short- and long-term efficacy, safety, and coronary artery patency following high-dose intravenous streptokinase in patients with acute myocardial infarction.
Administered 1 million international units of intravenous streptokinase over 30 or 60 minutes to 50 patients aged ≤70 years within 4 hours of acute myocardial infarction onset with ≥4 mm ST segment elevation.
Evaluated myocardial reperfusion using ST segment resolution, cardiac enzyme kinetics (creatine kinase, CK-MB, myoglobin), and delayed coronary arteriography, with a mean follow-up of 15 months.
Rapid ST segment resolution occurred in 36 of 50 patients (72%), and delayed coronary arteriography showed a patent infarct-related artery in 28 of 40 evaluated patients (70%).
Mean left ventricular ejection fraction was 57% in patients with a patent vessel compared to 48% in those with an occluded vessel.
Five of 50 patients (10%) died in-hospital and 4 died during follow-up, while rates of reinfarction, dyspnoea, and angina remained low over a mean 15-month follow-up.

Structured PICO

Does high dose intravenous streptokinase induce reperfusion in patients with acute myocardial infarction?

Population

50 patients aged ≤70 years with acute myocardial infarction (4 mm or greater ST segment elevation in anterior or inferior leads) treated 4 hours or less after the onset of symptoms.

Intervention

Streptokinase 1 million international units intravenously over 30 or 60 minutes.

Outcome

Reperfusion of the myocardium (indicated by rapid ST segment resolution, peak cardiac enzymes, and patency on delayed coronary arteriography).surrogate

Intravenous administration of high dose streptokinase during the acute phase of myocardial infarction is an effective method of thrombolysis, achieving a 70% patency rate in the infarct-related artery.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support IV streptokinase for reperfusion in acute MI; hypothesis-generating and requires randomized confirmation before practice change.

Cite This Study

MacLennan et al. (1986) studied this question.

synapsesocial.com/papers/6a110ba06da82ae745f33ee2 https://doi.org/10.1136/hrt.55.3.231

View Full Paper

Ask AI

Bookmark

Implication

May support IV streptokinase for reperfusion in acute MI; hypothesis-generating and requires randomized confirmation before practice change.

High dose intravenous streptokinase in acute myocardial infarction--short and long term prognosis.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

High dose intravenous streptokinase in acute myocardial infarction--short and long term prognosis.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider