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March 27, 2024Open Access

Intron-lariat spliceosomes convert lariats to true circles: implications for intron transposition

Manuel Ares Haller Igel Sol Katzman John P. Donohue

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Abstract

Rare, full length circular intron RNAs distinct from lariats have been reported in several species, but their biogenesis is not understood. We envision and test a hypothesis for their formation using

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Cite This Study

Ares et al. (2024) studied this question.

synapsesocial.com/papers/68e72200b6db64358769bb21 https://doi.org/10.1101/2024.03.26.586863

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Intron lariat spliceosomes convert lariats to true circles: implications for intron transposition2024 · 8 citations
2Group I permuted intron-exon (PIE) sequences self-splice to produce circular exonspreclinical · 1992 · 188 citations
3Interlocked circle formation by group I introns: structural requirements and mechanismpreclinical · 1993 · 3 citations
4Structural basis of circularly permuted group II intron self-splicing2024 · 8 citations
5Pre-splicing conformation and stepwise circularization of a group I intron in Azoarcus pre-tRNAOriginal Research · 2026 · 1 citations

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