Key result
Circularly permuted group I intron precursor RNAs successfully self-spliced in vitro, releasing the fused-exon as a circular RNA.
Circularly permuted group I introns can be used to generate short defined sequences of circular RNA in vitro and potentially in vivo.
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Circular permutation preserves self-splicing; extends intron architecture models but leaves open cellular applications.
Puttaraju et al. (1992) studied this question. Circularly permuted group I intron precursor RNAs was evaluated on Self-splicing activity and circular exon production. Circularly permuted group I intron precursor RNAs successfully self-spliced in vitro, releasing the fused-exon as a circular RNA.
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