Formulation and Evaluation of Edoxaban Sublingual Tablets Using HPMC as a Hydrophilic Polymer by Solid Dispersion Method

Since dose forms delivered sublingually avoid hepatic metabolism, sublingual drug administration may be a superior option than oral drug delivery.Certain medications, particularly those used to treat acute diseases, are frequently intended to have a quick beginning of pharmacological activity.Sublingual tablets dissolve quickly, and the small amount of saliva that is present is typically enough to cause the dose form to dissolve, improve solubility, and have a higher bioavailability.Compared to standard dosage forms, sublingual tablets were shown to have better properties.Because the pills disintegrated quickly, sublingual administration resulted in improved bioavailability, a quicker onset of action, and superior dissolving qualities.Super-disintegrants were added to promote quick disintegration; acute illnesses or emergency situations can be treated using this method.In conclusion, quick start of action, improved patient compliance, and higher bioavailability can all be attained with sublingual tablets or any other sublingual dosage form.Drugs that go through a lot of first pass metabolism or breakdown in the GIT can be administered sublingually.When compared to traditional oral tablets, drugs delivered sublingually typically have improved bioavailability, which correlates to dose reduction.